Sodium Channel Inhibitors Reduce DMPK mRNA and Protein
نویسندگان
چکیده
منابع مشابه
Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel.
We previously reported the existence of multiple isoforms of human Nedd4-2 (Am J Physiol Renal Physiol 285: F916-F929, 2003). When overexpressed in M-1 collecting duct epithelia, full-length Nedd4-2 (Nedd4-2), Nedd4-2 lacking the NH(2)-terminal C2 domain (Nedd4-2DeltaC2), and Nedd4-2 lacking WW domains 2 and 3 (Nedd4-2DeltaWW2,3) variably reduce benzamil-sensitive Na(+) transport. We investigat...
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ژورنال
عنوان ژورنال: Clinical and Translational Science
سال: 2015
ISSN: 1752-8054
DOI: 10.1111/cts.12275